Publications

Snider SA, Margison KD, Ghorbani P, LeBlond ND, O'Dwyer C, Nunes JR, Nguyen T, Xu H, Bennett SA, Fullerton MD. Choline transport links macrophage phospholipid metabolism and inflammation. J Biol Chem. 2018 Jun 7. pii: jbc.RA118.003180. doi: 10.1074/jbc.RA118.003180. [Epub ahead of print]

LeBlond ND, Fullerton MD. Methods to Evaluate AMPK Regulation of Macrophage Cholesterol Homeostasis. Methods Mol Biol. 2018;1732:477-493. doi: 10.1007/978-1-4939-7598-3_30.

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Sundaram M, Curtis KR, Amir Alipour M, LeBlond ND, Margison KD, Yaworski RA, Parks RJ, McIntyre AD, Hegele RA, Fullerton MD, Yao Z. The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation. J Lipid Res. 2017 Sep 8. pii: jlr.M077313. doi: 10.1194/jlr.M077313. [Epub ahead of print]

Cavallari JF, Fullerton MD, Duggan BM, Foley KP, Denou E, Smith BK, Desjardins EM, Henriksbo BD, Kim KJ, Tuinema BR, Stearns JC, Prescott D, Rosenstiel P, Coombes BK, Steinberg GR, Schertzer JD. Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4. Cell Metab. 2017 May 2;25(5):1063-1074.e3. doi: 10.1016/j.cmet.2017.03.021. Epub 2017 Apr 20.

Rollins M, Huard S, Morettin A, Takuski J, Pham TT, Fullerton MD, Côté J, Baetz K. Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae. PLoS Genet. 2017 Feb 23;13(2):e1006626.

Fullerton MD. AMP-activated protein kinase and its multifaceted regulation of hepatic metabolism. Current Opinions in Lipidology. Curr Opin Lipidol. 2016 Apr;27(2):172-80.

Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ. (2015). MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis. J Clin Invest. 2015 Oct 26;125(12):4334-48.

Katarina Marcinko, Sarah R. Sikkema, M. Constantine Samaan, Bruce E. Kemp, Morgan D. Fullerton, Gregory R. Steinberg. (2015). High intensity interval training improves liver and adipose tissue insulin sensitivity. Mol Metab. 2015 Oct 9;4(12):903-15.

Fullerton MD, Ford RJ, McGregor CP, LeBlond ND, Snider SA, Stypa SA, Day EA, Lhoták Š, Schertzer JD, Austin RC, Kemp BE, Steinberg GR. Salicylate improves macrophage cholesterol homeostasis via activation of Ampk. J Lipid Res. 2015 May;56(5):1025-33.

 
Ford RJ, Fullerton MD, Pinkosky SL, Day EA, Scott JW, Oakhill JS, Bujak AL, Smith BK, Crane JD, Blϋmer RM, Marcinko K, Kemp BE, Gerstein HC, Steinberg GR. Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity. Biochem J. 2015 May 15;468(1):125-32.
 
Denou E, Lolmède K, Garidou L, Pomie C, Chabo C, Lau TC, Fullerton MD, Nigro G, Zakaroff-Girard A, Luche E, Garret C, Serino M, Amar J, Courtney M, Cavallari JF, Henriksbo BD, Barra NG, Foley KP, McPhee JB, Duggan BM, O'Neill HM, Lee AJ, Sansonetti P, Ashkar AA, Khan WI, Surette MG, Bouloumié A, Steinberg GR, Burcelin R, Schertzer JD. Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance. EMBO Mol Med. 2015 Feb 9;7(3):259-74.
 
Crane JD, Palanivel R, Mottillo EP, Bujak AL, Wang H, Ford RJ, Collins A, Blümer RM,Fullerton MD, Yabut JM, Kim JJ, Ghia JE, Hamza SM, Morrison KM, Schertzer JD, Dyck JR, Khan WI, Steinberg GR. Inhibiting tryptophan hydroxylase 1 reduces obesity and the metabolic syndrome by promoting uncoupling protein-1 expression. Nature Medicine. 2015 Feb;21(2):166-72.
 
Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K. Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK. Chem Biol. 2014 Jul 17;21(7):866-79.
 
Henriksbo BD, Lau TC, Cavallari JF, Denou E, Fullerton MD, Tarnopolsky MA, Steinberg GR, Schertzer JD. Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance. Diabetes 2014 2014 Nov;63(11):3742-7
 
O'Neill HM, Lally JS, Galic S, Thomas M, Azizi PD, Fullerton MD, Smith BK, Pulinilkunnil T, Chen Z, Samaan MC, Jorgensen SB, Dyck JR, Holloway GP, Hawke TJ, van Denderen BJ, Kemp BE, Steinberg GR. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice. Diabetologia. 2014 Aug;57(8):1693-702.
 
Bujak A, Blümer RM, Marcinko K, Fullerton MD, Kemp BE, Steinberg GR. Reduced skeletal muscle AMPK and mitochondrial content does not promote the development of aging-induced insulin resistance.  J Appl Physiol (1985). 2014 Jul 15;117(2):171-9.
 
Bojic LA, Telford DE, Fullerton MD, Ford RJ, Sutherland BJ, Edwards JY, Sawyez CG, Gros R, Steinberg GR, and Huff MW. PPARδ-specific activation in liver attenuates triglyceride accumulation via enhanced fatty acid oxidation, reduced fatty acid synthesis and improved insulin sensitivity. J Lipid Res. 2014 May 26;55(7):1254-1266.
 
Samaan MC, Marcinko K, Sikkema S, Fullerton MD, Ziafazeli T, Khan MI, Steinberg GR. Endurance interval training in obese mice reduces muscle inflammation and macrophage content independently of weight loss. Physiol Rep. 2014 May 19;2(5). pii: e12012. doi: 10.14814/phy2.12012.
 
Fullerton MD and Steinberg GR. ‘Presenting’ an adaptive role for AMPK. Journal of Leukocyte Biology, 2013 Dec;94(6):1099-101.
 
Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, O'Neill HM, Ford RJ, Palanivel R, O’Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, Kemp BE, Steinberg GR. A single amino acid in Acc1 and Acc2 regulates lipid homeostasis and the insulin-sensitizing effects of metformin. Nature Medicine, 2013 Dec;19(12):1649-54.
 
Shulga YV, Loukov D, Ivanova PT, Milne SB, Myers DS, Hatch GM, Umeh G, Jalan D, Fullerton MD, Steinberg GR, Topham MK, Brown HA, Epand RM. Diacylglycerol Kinase Delta Promotes Lipogenesis. Biochemistry. 2013 Nov 5;52(44):7766-76.
 
Basseri S, Lhoták S, Fullerton MD, Palanivel R, Jiang H, Lynn EG, Ford RJ, Maclean KN, Steinberg GR, Austin RCLoss of TDAG51 results in mature-onset obesity, hepatic steatosis, and insulin resistance by regulating adipogenesis and lipogenesis. Diabetes. 2013 Jan;62(1):158-69.
 
Jorgensen SB, O’Neill HM, Sylow L, Honeyman J, Hewitt KA, Palanivel R, Fullerton MD, Öberg L, Balendran A, Galic S, van der Poel C, Trounce IA, Lynch GS, Schertzer JD, Steinberg GR. Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity. Diabetes. 2013 Jan;62(1):56-64.
 
Palanivel R, Fullerton MD, Galic S, Honeyman J, Hewitt KA, Jorgensen SB, Steinberg GR. Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance. Diabetologia. 2012 Nov;55(11):3083-93.
 
Singh RK, Fullerton MD, Vine D, Bakovic M. Mechanisms of hypertriglyceridemia in CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) deficient mice. J Lipid Res. 2012 Sept;53(9):1811-22.
 
Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR and Hardie DG. The ancient drug salicylate directly activates AMP-activated protein kinase. Science. 2012 May 18;336(6083):918-22.
 
Fullerton MD, Steinberg GR, Schertzer JD. Immunometabolism of AMPK in insulin resistance and atherosclerosis. Mol Cell Endocrinol. 2012, Feb 25;366(2):224-34.
 
Fullerton MD*, Galic S*,  Schertzer JD, Honeyman J, Walkley CR, Campbell DJ, van Denderen B, Kemp BE and Steinberg GR. Hematopoietic deletion of AMPK β1 exacerbates inflammation and hepatic insulin resistance in obesity. J Clin Invest. 2011 Dec;121(12):4903-15.
 
Schertzer JD, Tamrakar AK, Magalhães JG, Pereira S, Bilan PJ, Fullerton MD, Philpott DJ, Steinberg GR, Giacca A and Klip A. NOD1 activators link innate immunity and insulin resistance. Diabetes. 2011, Sep;60(9):2206-15.
 
Fullerton MD, Bakovic M. Complementation of the metabolic defect in CTP: phosphoethanolamine cytidylyltransferase (Pcyt2) deficient primary hepatocytes. Metabolism 2010 Dec;59(12):1691-700.
 
Fullerton MD, Steinberg GR. SirT1 takes a back seat to AMPK in the regulation of insulin sensitivity by resveratrol. Diabetes 2010 Mar;59(3):551-3.
 
Fullerton MD, Hakimuddin F, Bonen A, Bakovic M. The Development of a Metabolic Disease Phenotype in CTP:Phosphoethanolamine Cytidylyltransferase-deficient Mice. J Biol Chem. 2009 Sep 18; 284(38):25704-13.
 
Wood KC, Fullerton MD, El-Sohemy A, Bakovic M. Interactions between hepatic lipase and apolipoprotein E gene polymorphismsaffect serum lipid profiles of healthy Canadian adults. Appl Physiol Nutr Metab. 2008 Aug; 33(4): 761-8.
 
Bakovic M, Fullerton MD, Michel V. Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2). Biochem Cell Biol. 2007 Jun; 85(3): 283-300. Invited Review.
 
Fullerton MD, Hakimuddin F, Bakovic M. Developmental and metabolic effects of disruption of the mouse CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2). Mol Cell Biol. 2007 May; 27(9): 3327-36.
 
Fullerton MD, Wagner L, Yuan Z, Bakovic M. Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages. Am J Physiol Cell Physiol. 2006 Apr; 290 (4): C1230-8.