Publications

Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required.

Petrick HL, Foley KP, Zlitni S, Brunetta HS, Paglialunga S, Miotto PM, Politis-Barber V, O'Dwyer C, Philbrick DJ, Fullerton MD, Schertzer JD, Holloway GP. Function (Oxf). 2020 Aug 25;1(2):zqaa013. doi: 10.1093/function/zqaa013. eCollection 2020. PMID: 34278304

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Metformin again? Atheroprotection mediated by macrophage AMPK and ATF1.

Salt IP, Nunes JRC, Fullerton MD. Cardiovasc Res. 2021 Apr 23;117(5):1233-1234. doi: 10.1093/cvr/cvab065. PMID: 33681999

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Ebola virus triggers receptor tyrosine kinase-dependent signaling to promote the delivery of viral particles to entry-conducive intracellular compartments.

Stewart CM, Phan A, Bo Y, LeBlond ND, Smith TKT, Laroche G, Giguère PM, Fullerton MD, Pelchat M, Kobasa D, Côté M. PLoS Pathog. 2021 Jan 29;17(1):e1009275. doi: 10.1371/journal.ppat.1009275. eCollection 2021 Jan. PMID: 33513206

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Foam Cell Induction Activates AMPK But Uncouples Its Regulation of Autophagy and Lysosomal Homeostasis.

LeBlond ND, Nunes JRC, Smith TKT, O'Dwyer C, Robichaud S, Gadde S, Côté M, Kemp BE, Ouimet M, Fullerton MD. Int J Mol Sci. 2020 Nov 27;21(23):9033. doi: 10.3390/ijms21239033. PMID: 33261140

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Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK.

Banskota S, Wang H, Kwon YH, Gautam J, Gurung P, Haq S, Hassan FMN, Bowdish DM, Kim JA, Carling D, Fullerton MD, Steinberg GR, Khan WI. Inflamm Bowel Dis. 2021 May 17;27(6):914-926. doi: 10.1093/ibd/izaa305. PMID: 33252129

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Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice.

LeBlond ND, Ghorbani P, O'Dwyer C, Ambursley N, Nunes JRC, Smith TKT, Trzaskalski NA, Mulvihill EE, Viollet B, Foretz M, Fullerton MD. J Lipid Res. 2020 Dec;61(12):1697-1706. doi: 10.1194/jlr.RA120001040. Epub 2020 Sep 25. PMID: 32978273

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​​​​Hepatic Choline Transport Is Inhibited During Fatty Acid-Induced Lipotoxicity and Obesity.

O'Dwyer C, Yaworski R, Katsumura S, Ghorbani P, Gobeil Odai K, Nunes JRC, LeBlond ND, Sanjana S, Smith TTK, Han S, Margison KD, Alain T, Morita M, Fullerton MD. Hepatol Commun. 2020 Apr 10;4(6):876-889. doi: 10.1002/hep4.1516. eCollection 2020 Jun. PMID: 32490323

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The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK.

Morrow NM, Burke AC, Samsoondar JP, Seigel KE, Wang A, Telford DE, Sutherland BG, O'Dwyer C, Steinberg GR, Fullerton MD, Huff MW. J Lipid Res. 2020 Mar;61(3):387-402. doi: 10.1194/jlr.RA119000542. Epub 2020 Jan 21. PMID: 31964763

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In Vitro Hepatitis C Virus Infection and Hepatic Choline Metabolism.

Gobeil Odai K, O'Dwyer C, Steenbergen R, Shaw TA, Renner TM, Ghorbani P, Rezaaifar M, Han S, Langlois MA, Crawley AM, Russell RS, Pezacki JP, Tyrrell DL, Fullerton MD. Viruses. 2020 Jan 16;12(1):108. doi: 10.3390/v12010108. PMID: 31963173

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Characterization of Redox-Responsive LXR-Activating Nanoparticle Formulations in Primary Mouse Macrophages.

Smith TKT, Kahiel Z, LeBlond ND, Ghorbani P, Farah E, Al-Awosi R, Cote M, Gadde S, Fullerton MD. Molecules. 2019 Oct 18;24(20):3751. doi: 10.3390/molecules24203751. PMID: 31635211

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Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity.

McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME. FASEB J. 2019 Dec;33(12):13515-13526. doi: 10.1096/fj.201901150R. Epub 2019 Oct 3. PMID: 31581846

Screenshot 2021-08-17 at 15-10-13 Maternal diet‐induced obesity alters muscle mitochondria

A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells.

Stewart CM, Dorion SS, Ottenbrite MAF, LeBlond ND, Smith TKT, Qiu S, Fullerton MD, Kobasa D, Côté M. Viruses. 2019 Mar 1;11(3):206. doi: 10.3390/v11030206. PMID: 30832223

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AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles.

Losier TT, Akuma M, McKee-Muir OC, LeBlond ND, Suk Y, Alsaadi RM, Guo Z, Reshke R, Sad S, Campbell-Valois FX, Gibbings DJ, Fullerton MD, Russell RC. Cell Rep. 2019 Feb 19;26(8):2150-2165.e5. doi: 10.1016/j.celrep.2019.01.062. PMID: 30784596

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Interleukin-18 up-regulates amino acid transporters and facilitates amino acid-induced mTORC1 activation in natural killer cells.

Almutairi SM, Ali AK, He W, Yang DS, Ghorbani P, Wang L, Fullerton MD, Lee SH. J Biol Chem. 2019 Mar 22;294(12):4644-4655. doi: 10.1074/jbc.RA118.005892. Epub 2019 Jan 29. PMID: 30696773

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Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance.

Loh K, Tam S, Murray-Segal L, Huynh K, Meikle PJ, Scott JW, van Denderen B, Chen Z, Steel R, LeBlond ND, Burkovsky LA, O'Dwyer C, Nunes JRC, Steinberg GR, Fullerton MD, Galic S, Kemp BE. Hepatol Commun. 2018 Nov 12;3(1):84-98. doi: 10.1002/hep4.1279. eCollection 2019 Jan. PMID: 30619997

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A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling.

van der Veen JN, Lingrell S, McCloskey N, LeBlond ND, Galleguillos D, Zhao YY, Curtis JM, Sipione S, Fullerton MD, Vance DE, Jacobs RL. FASEB J. 2019 Apr;33(4):5045-5057. doi: 10.1096/fj.201802117R. Epub 2019 Jan 7. PMID: 30615497

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Does prenylation predict progression in NAFLD?

Ghorbani P, Smith TK, Fullerton MD. J Pathol. 2019 Mar;247(3):283-286. doi: 10.1002/path.5190. Epub 2018 Dec 27. PMID: 30374976

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Choline transport links macrophage phospholipid metabolism and inflammation.

Snider SA, Margison KD, Ghorbani P, LeBlond ND, O'Dwyer C, Nunes JRC, Nguyen T, Xu H, Bennett SAL, Fullerton MD. J Biol Chem. 2018 Jul 20;293(29):11600-11611. doi: 10.1074/jbc.RA118.003180. Epub 2018 Jun 7. PMID: 29880645

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Methods to Evaluate AMPK Regulation of Macrophage Cholesterol Homeostasis.

LeBlond ND, Fullerton MD. Methods Mol Biol. 2018;1732:477-493. doi: 10.1007/978-1-4939-7598-3_30. PMID: 29480494

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The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation.

Sundaram M, Curtis KR, Amir Alipour M, LeBlond ND, Margison KD, Yaworski RA, Parks RJ, McIntyre AD, Hegele RA, Fullerton MD, Yao Z. J Lipid Res. 2017 Nov;58(11):2188-2196. doi: 10.1194/jlr.M077313. Epub 2017 Sep 8. PMID: 28887372

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Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae.

Rollins M, Huard S, Morettin A, Takuski J, Pham TT, Fullerton MD, Côté J, Baetz K. PLoS Genet. 2017 Feb 23;13(2):e1006626. doi: 10.1371/journal.pgen.1006626. eCollection 2017 Feb. PMID: 28231279

AMP-activated protein kinase and its multifaceted regulation of hepatic metabolism.

Fullerton MD. Curr Opin Lipidol. 2016 Apr;27(2):172-80. doi: 10.1097/MOL.0000000000000273. PMID: 26906549 Review.

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MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis.

Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ. J Clin Invest. 2015 Oct 26;125(12):4334-48. doi: 10.1172/JCI81676. PMID: 26517695

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Salicylate improves macrophage cholesterol homeostasis via activation of Ampk.

Fullerton MD, Ford RJ, McGregor CP, LeBlond ND, Snider SA, Stypa SA, Day EA, Lhoták Š, Schertzer JD, Austin RC, Kemp BE, Steinberg GR. J Lipid Res. 2015 May;56(5):1025-33. doi: 10.1194/jlr.M058875. Epub 2015 Mar 15. PMID: 25773887

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