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Publications

Click here for our lab's publications via PubMed

AMPK-mediated regulation of endogenous cholesterol synthesis does not affect atherosclerosis in a murine Pcsk9-AAV model.

Smith TKT, Ghorbani P, LeBlond ND, Nunes JRC, O'Dwyer C, Ambursley N, Fong-McMaster C, Minarrieta L, Burkovsky LA, El-Hakim R, Trzaskalski NA, Locatelli CAA, Stotts C, Pember C, Rayner KJ, Kemp BE, Loh K, Harper ME, Mulvihill EE, St-Pierre J, Fullerton MD. Atherosclerosis. 2024 Jun 3:117608. doi: 10.1016/j.atherosclerosis.2024.117608. Online ahead of print. PMID: 38880706

Myeloid AMPK signaling restricts fibrosis but is not required for metformin improvements during CDAHFD-induced NASH in mice.

Nunes JRC, O'Dwyer C, Ghorbani P, Smith TKT, Chauhan S, Robert-Gostlin V, Girouard MD, Viollet B, Foretz M, Fullerton MD. J Lipid Res. 2024 Jun;65(6):100564. doi: 10.1016/j.jlr.2024.100564. Epub 2024 May 17. PMID: 38762124

The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice.

Hoyeck MP, Angela Ching ME, Basu L, van Allen K, Palaniyandi J, Perera I, Poleo-Giordani E, Hanson AA, Ghorbani P, Fullerton MD, Bruin JE. Mol Metab. 2024 Mar;81:101893. doi: 10.1016/j.molmet.2024.101893. Epub 2024 Feb 2. PMID: 38309623

Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice.

Day EA, Townsend LK, Rehal S, Batchuluun B, Wang D, Morrow MR, Lu R, Lundenberg L, Lu JH, Desjardins EM, Smith TKT, Raphenya AR, McArthur AG, Fullerton MD, Steinberg GR. iScience. 2023 Oct 20;26(11):108269. doi: 10.1016/j.isci.2023.108269. eCollection 2023 Nov 17. PMID: 38026185

Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection.

Ghorbani P, Kim SY, Smith TKT, Minarrieta L, Robert-Gostlin V, Kilgour MK, Ilijevska M, Alecu I, Snider SA, Margison KD, Nunes JRC, Woo D, Pember C, O'Dwyer C, Ouellette J, Kotchetkov P, St-Pierre J, Bennett SAL, Lacoste B, Blais A, Nair MG, Fullerton MD. PLoS Pathog. 2023 Sep 25;19(9):e1011658. doi: 10.1371/journal.ppat.1011658. eCollection 2023 Sep. PMID: 37747879

Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress.

Fadzeyeva E, Locatelli CAA, Trzaskalski NA, Nguyen MA, Capozzi ME, Vulesevic B, Morrow NM, Ghorbani P, Hanson AA, Lorenzen-Schmidt I, Doyle MA, Seymour R, Varin EM, Fullerton MD, Campbell JE, Mulvihill EE. iScience. 2023 Apr 26;26(5):106748. doi: 10.1016/j.isci.2023.106748. eCollection 2023 May 19. PMID: 37216093

Thermoneutral housing does not accelerate metabolic dysfunction-associated fatty liver disease in male or female C57Bl/6J mice fed a Western diet.

Nunes JRC, Smith TKT, Ghorbani P, O'Dwyer C, Trzaskalski NA, Dergham H, Pember C, Kilgour MK, Mulvihill EE, Fullerton MD. Am J Physiol Endocrinol Metab. 2023 Jul 1;325(1):E10-E20. doi: 10.1152/ajpendo.00124.2023. Epub 2023 May 17. PMID: 37196059

Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression.

Trzaskalski NA, Vulesevic B, Nguyen MA, Jeraj N, Fadzeyeva E, Morrow NM, Locatelli CA, Travis N, Hanson AA, Nunes JR, O'Dwyer C, van der Veen JN, Lorenzen-Schmidt I, Seymour R, Pulente SM, Clément AC, Crawley AM, Jacobs RL, Doyle MA, Cooper CL, Kim KH, Fullerton MD, Mulvihill EE. JCI Insight. 2023 Jan 24;8(2):e154314. doi: 10.1172/jci.insight.154314. PMID: 36472923

Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity.

Pileggi CA, Blondin DP, Hooks BG, Parmar G, Alecu I, Patten DA, Cuillerier A, O'Dwyer C, Thrush AB, Fullerton MD, Bennett SA, Doucet É, Haman F, Cuperlovic-Culf M, McPherson R, Dent RRM, Harper ME. EBioMedicine. 2022 Sep;83:104192. doi: 10.1016/j.ebiom.2022.104192. Epub 2022 Aug 11.

Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization.

Pham T, Walden E, Huard S, Pezacki J, Fullerton MD, Baetz K. Genetics. 2022 Jul 30;221(4):iyac086. doi: 10.1093/genetics/iyac086.

Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis.

Lee MKS, Cooney OD, Lin X, Nadarajah S, Dragoljevic D, Huynh K, Onda DA, Galic S, Meikle PJ, Edlund T, Fullerton MD, Kemp BE, Murphy AJ, Loh K. Mol Metab. 2022 Jul;61:101514. doi: 10.1016/j.molmet.2022.101514. Epub 2022 May 10. PMID: 35562083

Salsalate reduces atherosclerosis through AMPKβ1 in mice.

Day EA, Ford RJ, Smith BK, Houde VP, Stypa S, Rehal S, Lhotak S, Kemp BE, Trigatti BL, Werstuck GH, Austin RC, Fullerton MD, Steinberg GR. Mol Metab. 2021 Nov;53:101321. doi: 10.1016/j.molmet.2021.101321. Epub 2021 Aug 21. PMID: 34425254

Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required.

Petrick HL, Foley KP, Zlitni S, Brunetta HS, Paglialunga S, Miotto PM, Politis-Barber V, O'Dwyer C, Philbrick DJ, Fullerton MD, Schertzer JD, Holloway GP. Function (Oxf). 2020 Aug 25;1(2):zqaa013. doi: 10.1093/function/zqaa013. eCollection 2020. PMID: 34278304

Screenshot 2021-08-17 at 15-29-55 Adipose Tissue Inflammation Is Directly Linked to Obesit

Metformin again? Atheroprotection mediated by macrophage AMPK and ATF1.

Salt IP, Nunes JRC, Fullerton MD. Cardiovasc Res. 2021 Apr 23;117(5):1233-1234. doi: 10.1093/cvr/cvab065. PMID: 33681999

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Ebola virus triggers receptor tyrosine kinase-dependent signaling to promote the delivery of viral particles to entry-conducive intracellular compartments.

Stewart CM, Phan A, Bo Y, LeBlond ND, Smith TKT, Laroche G, Giguère PM, Fullerton MD, Pelchat M, Kobasa D, Côté M. PLoS Pathog. 2021 Jan 29;17(1):e1009275. doi: 10.1371/journal.ppat.1009275. eCollection 2021 Jan. PMID: 33513206

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Foam Cell Induction Activates AMPK But Uncouples Its Regulation of Autophagy and Lysosomal Homeostasis.

LeBlond ND, Nunes JRC, Smith TKT, O'Dwyer C, Robichaud S, Gadde S, Côté M, Kemp BE, Ouimet M, Fullerton MD. Int J Mol Sci. 2020 Nov 27;21(23):9033. doi: 10.3390/ijms21239033. PMID: 33261140

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Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK.

Banskota S, Wang H, Kwon YH, Gautam J, Gurung P, Haq S, Hassan FMN, Bowdish DM, Kim JA, Carling D, Fullerton MD, Steinberg GR, Khan WI. Inflamm Bowel Dis. 2021 May 17;27(6):914-926. doi: 10.1093/ibd/izaa305. PMID: 33252129

Screenshot 2021-08-17 at 15-28-04 Salicylates Ameliorate Intestinal Inflammation by Activa

Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice.

LeBlond ND, Ghorbani P, O'Dwyer C, Ambursley N, Nunes JRC, Smith TKT, Trzaskalski NA, Mulvihill EE, Viollet B, Foretz M, Fullerton MD. J Lipid Res. 2020 Dec;61(12):1697-1706. doi: 10.1194/jlr.RA120001040. Epub 2020 Sep 25. PMID: 32978273

Screenshot 2021-08-17 at 15-25-26 Myeloid deletion and therapeutic activation of AMPK do n

​​​​Hepatic Choline Transport Is Inhibited During Fatty Acid-Induced Lipotoxicity and Obesity.

O'Dwyer C, Yaworski R, Katsumura S, Ghorbani P, Gobeil Odai K, Nunes JRC, LeBlond ND, Sanjana S, Smith TTK, Han S, Margison KD, Alain T, Morita M, Fullerton MD. Hepatol Commun. 2020 Apr 10;4(6):876-889. doi: 10.1002/hep4.1516. eCollection 2020 Jun. PMID: 32490323

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The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK.

Morrow NM, Burke AC, Samsoondar JP, Seigel KE, Wang A, Telford DE, Sutherland BG, O'Dwyer C, Steinberg GR, Fullerton MD, Huff MW. J Lipid Res. 2020 Mar;61(3):387-402. doi: 10.1194/jlr.RA119000542. Epub 2020 Jan 21. PMID: 31964763

Screenshot 2021-08-17 at 15-13-28 The citrus flavonoid nobiletin confers protection from m

In Vitro Hepatitis C Virus Infection and Hepatic Choline Metabolism.

Gobeil Odai K, O'Dwyer C, Steenbergen R, Shaw TA, Renner TM, Ghorbani P, Rezaaifar M, Han S, Langlois MA, Crawley AM, Russell RS, Pezacki JP, Tyrrell DL, Fullerton MD. Viruses. 2020 Jan 16;12(1):108. doi: 10.3390/v12010108. PMID: 31963173

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Characterization of Redox-Responsive LXR-Activating Nanoparticle Formulations in Primary Mouse Macrophages.

Smith TKT, Kahiel Z, LeBlond ND, Ghorbani P, Farah E, Al-Awosi R, Cote M, Gadde S, Fullerton MD. Molecules. 2019 Oct 18;24(20):3751. doi: 10.3390/molecules24203751. PMID: 31635211

Screenshot 2021-08-17 at 15-11-25 Characterization of Redox-Responsive LXR-Activating Nano

Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity.

McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME. FASEB J. 2019 Dec;33(12):13515-13526. doi: 10.1096/fj.201901150R. Epub 2019 Oct 3. PMID: 31581846

Screenshot 2021-08-17 at 15-10-13 Maternal diet‐induced obesity alters muscle mitochondria

A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells.

Stewart CM, Dorion SS, Ottenbrite MAF, LeBlond ND, Smith TKT, Qiu S, Fullerton MD, Kobasa D, Côté M. Viruses. 2019 Mar 1;11(3):206. doi: 10.3390/v11030206. PMID: 30832223

Screenshot 2021-08-17 at 15-04-31 A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filo

AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles.

Losier TT, Akuma M, McKee-Muir OC, LeBlond ND, Suk Y, Alsaadi RM, Guo Z, Reshke R, Sad S, Campbell-Valois FX, Gibbings DJ, Fullerton MD, Russell RC. Cell Rep. 2019 Feb 19;26(8):2150-2165.e5. doi: 10.1016/j.celrep.2019.01.062. PMID: 30784596

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Interleukin-18 up-regulates amino acid transporters and facilitates amino acid-induced mTORC1 activation in natural killer cells.

Almutairi SM, Ali AK, He W, Yang DS, Ghorbani P, Wang L, Fullerton MD, Lee SH. J Biol Chem. 2019 Mar 22;294(12):4644-4655. doi: 10.1074/jbc.RA118.005892. Epub 2019 Jan 29. PMID: 30696773

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Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance.

Loh K, Tam S, Murray-Segal L, Huynh K, Meikle PJ, Scott JW, van Denderen B, Chen Z, Steel R, LeBlond ND, Burkovsky LA, O'Dwyer C, Nunes JRC, Steinberg GR, Fullerton MD, Galic S, Kemp BE. Hepatol Commun. 2018 Nov 12;3(1):84-98. doi: 10.1002/hep4.1279. eCollection 2019 Jan. PMID: 30619997

Screenshot 2021-08-17 at 15-03-36 Inhibition of Adenosine Monophosphate–Activated Protein

A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling.

van der Veen JN, Lingrell S, McCloskey N, LeBlond ND, Galleguillos D, Zhao YY, Curtis JM, Sipione S, Fullerton MD, Vance DE, Jacobs RL. FASEB J. 2019 Apr;33(4):5045-5057. doi: 10.1096/fj.201802117R. Epub 2019 Jan 7. PMID: 30615497

Screenshot 2021-08-17 at 14-56-25 A role for phosphatidylcholine and phosphatidylethanolam

Does prenylation predict progression in NAFLD?

Ghorbani P, Smith TK, Fullerton MD. J Pathol. 2019 Mar;247(3):283-286. doi: 10.1002/path.5190. Epub 2018 Dec 27. PMID: 30374976

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Choline transport links macrophage phospholipid metabolism and inflammation.

Snider SA, Margison KD, Ghorbani P, LeBlond ND, O'Dwyer C, Nunes JRC, Nguyen T, Xu H, Bennett SAL, Fullerton MD. J Biol Chem. 2018 Jul 20;293(29):11600-11611. doi: 10.1074/jbc.RA118.003180. Epub 2018 Jun 7. PMID: 29880645

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Methods to Evaluate AMPK Regulation of Macrophage Cholesterol Homeostasis.

LeBlond ND, Fullerton MD. Methods Mol Biol. 2018;1732:477-493. doi: 10.1007/978-1-4939-7598-3_30. PMID: 29480494

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The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation.

Sundaram M, Curtis KR, Amir Alipour M, LeBlond ND, Margison KD, Yaworski RA, Parks RJ, McIntyre AD, Hegele RA, Fullerton MD, Yao Z. J Lipid Res. 2017 Nov;58(11):2188-2196. doi: 10.1194/jlr.M077313. Epub 2017 Sep 8. PMID: 28887372

Screenshot 2021-08-17 at 21-14-13 The apolipoprotein C-III (Gln38Lys) variant associated w

​Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae.

Rollins M, Huard S, Morettin A, Takuski J, Pham TT, Fullerton MD, Côté J, Baetz K. PLoS Genet. 2017 Feb 23;13(2):e1006626. doi: 10.1371/journal.pgen.1006626. eCollection 2017 Feb. PMID: 28231279

AMP-activated protein kinase and its multifaceted regulation of hepatic metabolism.

Fullerton MD. Curr Opin Lipidol. 2016 Apr;27(2):172-80. doi: 10.1097/MOL.0000000000000273. PMID: 26906549 Review.

Screenshot 2021-08-17 at 14-51-21 Lysine acetyltransferase NuA4 and acetyl-CoA regulate gl
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MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis.

Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ. J Clin Invest. 2015 Oct 26;125(12):4334-48. doi: 10.1172/JCI81676. PMID: 26517695

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Salicylate improves macrophage cholesterol homeostasis via activation of Ampk.

Fullerton MD, Ford RJ, McGregor CP, LeBlond ND, Snider SA, Stypa SA, Day EA, Lhoták Š, Schertzer JD, Austin RC, Kemp BE, Steinberg GR. J Lipid Res. 2015 May;56(5):1025-33. doi: 10.1194/jlr.M058875. Epub 2015 Mar 15. PMID: 25773887

Screenshot 2021-08-17 at 21-14-48 Salicylate improves macrophage cholesterol homeostasis v
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