In the Fullerton lab, we study immunometabolism- the interplay between metabolism and immunity. Much of our research has a specific focus on lipid homeostasis in metabolic and innate immune cells. Our research aims to uncover some of the underlying mechanisms by which metabolic and immune processes are altered in chronic diseases such as insulin resistance (which leads to type 2 diabetes), atherosclerosis (which leads to heart disease) and fatty liver disease.
We use genetically engineered (knock-out and knock-in) mice that have targeted changes to specific metabolic or immune pathways, in combination with molecular, biochemical and cellular biology techniques, to look at changes in whole-body physiology and metabolism The overall aims are to better understand how these pathways function, in normal and diseased conditions, so to potentially develop novel strategies to prevent and treat chronic metabolic diseases. To learn more about our research, team and what we've been up to, see the video and links below or above.
Scientists with brooms...
Curling with the Mulvihill and D'Costa labs